The Dutch experiment has led to the death of 11 infants

Between 10 and 15 more women now face an anxious wait to see if their unborn children will be affected.

An interim analysis found the chance of blood vessel disease in the lungs "appears to be greater and the chance of death after birth seems to have increased".

The research was being carried out at 10 hospital sites in the Netherlands, with the aim of discovering whether sildenafil could improve blood flow through underperforming placentas.

Pfizer held the drug's patent until December.

During the study, another 90 women took a placebo pill with no active ingredients. Among a control group of roughly an equal size, there were only three babies with lung issues and no deaths.

A similar United Kingdom trial, the results of which were published in December, found no difference in neonatal deaths, and no adverse affects were linked to the drug.

Researchers conducting a similar trial in Canada have been notified and have suspended their research. It was aimed at increasing the blood flow to the placenta in cases where unborn babies were critically undeveloped.

But out of the 93 women using the drug, 19 babies died, 11 of them possibly due to a form of high blood pressure in the lungs which may be linked to the drug. Growth restriction is diagnosed using ultrasound, but now the only medical treatment is closely monitoring the pregnancy and inducing birth when the risk of stillbirth is deemed high. Outside of research studies with explicit participants' consent, they said physicians should stop prescribing sildenafil for fetal growth restriction.

"We are using Sildenafil in women with full-term pregnancies who are appropriately grown".

Lead investigator Wessel Ganzevoort could not tell Nieuwsuur exactly how many now still pregnant women were prescribed the drug. Spokeswoman Dervila Keane wrote in an email Tuesday that the research is "an investigator initiated study and Pfizer have no involvement in the trial".

SIL, aka Viagra, is a drug approved by the Federal Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of erectile dysfunction and pulmonary hypertension in adults. That poses a hard dilemma for doctors: Inducing birth too early increases the risk of complications, but waiting too long could lead to developmental anomalies or stillbirth.

Low birth weight contributes to 60% to 80% of neonatal deaths worldwide, according to the World Health Organization. reported in March on the results of a study that involved 122 Australian and New Zealand women, half of whom received sildenafil.

Huf-Germain said she did not recall being told of any risks to her child at the start of the trial, but such was the desperation of the women involved that few would have comprehended the possible consequences.

(Copyright © 2015. All Rights Reserved.)

Facebook Suffers Huge One-Day Drop in Market Value
In North America, the daily user number was flat at 185 million, and in Europe it actually declined by three million people a day. It wasn't since the turn of the century almost two decades ago that anything close to such a huge loss was registered in the U.S.

Century's longest lunar eclipse tonight: All you need to know
Although no longer directly illuminated by the Sun, the moon still catches light filtered and bent by the Earth's atmosphere. In addition, the event will also be visible in parts of South-America, parts of Europe, Africa, Asia, Australia.

Serena Williams hits out again at 'random' dope testing 'discrimination'
She said: "How is it I'm getting tested five times in June?" "It's just about being equal and not centring one person out". But the seven-time Wimbledon champion also made it clear she didn't expect to have been tested so often this year.

Trump claims United States is ‘economic envy of the entire world’
Americans spent liberally on health care, housing, utilities, restaurants and hotels, according to the Commerce Department data. That revision showed that growth in 2017 came in at 2.2 per cent, slightly lower than the 2.3 per cent previously reported.

Frenchman Julian Alaphilippe wins Tour de France's first mountain stage
Reports from the road said police then used spray to remove them, but that spray blew back into riders' faces. Local authorities said in a statement that an investigation into the incidents had been opened.

Trump denies knowing of 2016 Trump Tower meeting with Russians
If true, it would also mean that Donald Trump Jr . lied about his father's knowledge of this to congressional investigators. The statement, made by Trump in morning tweets, escalates the public feud between the president and his longtime fixer.

Twitter Shares Fall, Ending A Hard Week For Social Media Stocks
"Our second quarter results reflect the work we're doing to ensure more people get value from Twitter every day", he said. Markets outside the USA grew 44% year on year to $US344 million.

Five men charged over ‘acid attack’ on three-year-old boy
The five men were charged with "conspiracy to commit grievous bodily harm", West Mercia police said in a statement. The five men are scheduled to return to court August 28.

Ex-lawyer claims Trump knew of 2016 meeting with Russians
The network host stated the meeting "falls a long way from any hint of collusion between Trump and the Kremlin". Lanny Davis , the lawyer for Michael Cohen , accused the Trump legal team of leaking the report.

Second-quarter GDP surges to 4.1 percent, showing strength of 'Trump economy'
Consumer spending grew 4 percent , more than estimated, while nonresidential business investment climbed at a 7.3 percent clip. That revision showed that growth in 2017 came in at 2.2 per cent, slightly lower than the 2.3 per cent previously reported .

Acting New Zealand prime minister asks Australia to change its flag
When New Zealand slalom canoeist Luuka Jones won silver at the Rio Olympics, officials commemorated her with an Australian flag . But in 2016, after a finalist for a new flag had been selected, nearly 57 percent of Kiwis opted to keep their old flag.

President Putin invites Donald Trump to Moscow
Reagan said that Trump's base would support Putin for president of the United States over any Democrat. Trump faced a storm of criticism back home for his handling of the meeting.

Disney, Fox deal will result in blockbusters, IMAX CEO says
However, Comcast dropped out of the running earlier this month, clearing the path for Disney to move forward with its purchase. Fox had 21,700 employees at year-end, according to data compiled by Bloomberg, while Disney has 199,000.

Flash Flood Watch In Effect For Most Of Maryland
Sunday will be the next big day to watch as severe weather and very heavy rain look to make their return into the afternoon. They say Saturday's storm hit totals of 4 to 6 inches in some spots, with other areas getting 7 inches or more.

Trump knew about Trump Tower meeting with Russians, Cohen source to CNN
In the tape, the two men discuss how to buy the rights to a former Playboy model's story of her affair with Trump. Michael Cohen is now apparently saying Trump knew, while Trump took to Twitter this morning to adamantly deny it.

More News

More News